Article

Early and late chaperone intervention therapy boosts XBP1s and ADAM10, restores proteostasis, and rescues learning in Alzheimer’s Disease mice

2023-05-24

Abstract excerpt

Alzheimer’s disease (AD) is a debilitating neurodegenerative disorder that is pervasive among the aging population. Two distinct phenotypes of AD are deficits in cognition and proteostasis, including chronic activation of the unfolded protein response (UPR) and aberrant Aβ production. It is unknown if restoring proteostasis by reducing chronic and aberrant UPR activation in AD can improve pathology and cognition....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 13288261-465d-5068-b4cc-c90439fa1510
DOI: 10.1101/2023.05.23.541973

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Early and late chaperone intervention therapy boosts XBP1s and ADAM10, restores proteostasis, and rescues learning in Alzheimer’s Disease miceDOI 10.1101/2023.05.23.541973Read

Alzheimer's Disease and Molecular Chaperones: Current Knowledge and the Future of ChaperonotherapySemantic proximity Read

The unfolded protein response transcription factor XBP1s ameliorates Alzheimer’s disease by improving synaptic function and proteostasisSemantic proximity Read

Optimized AAV to express the unfolded protein response transcription factor XBP1s ameliorates Alzheimer’s disease features in mouse modelsSemantic proximity Read

The chaperones HSP90AA1, HSP90AB1 and BAG3 are specifically distributed among human hippocampal subfields during different Alzheimer's disease stagesSemantic proximity Read

Transcriptomic analysis reveals new reparative mechanisms of SCF+G-CSF-reduced neuropathology in aged APP/PS1 miceSemantic proximity Read

Control of mammalian brain ageing by the unfolded protein response transcription factor XBP1Semantic proximity Read

Identification and drug-induced reversion of molecular signatures of Alzheimer’s disease onset and progression in AppNL-G-F, AppNL-F, and 3xTg-AD mouse modelsSemantic proximity Read

Therapeutic effect of exogenous hsp70 in mouse models of Alzheimer's disease.Semantic proximity Read

Pharmacological intervention in a transgenic mouse model improves Alzheimer's-associated pathological phenotype: Involvement of proteasome activation.Semantic proximity Read

Behavioral and neural network abnormalities in human APP transgenic mice resemble those of App knock-in mice and are modulated by familial Alzheimer's disease mutations but not by inhibition of BACE1.Semantic proximity Read

Increased levels of Stress-inducible phosphoprotein-1 accelerates amyloid-β deposition in a mouse model of Alzheimer’s diseaseSemantic proximity Read

Fine‐tuning PERK signaling for neuroprotectionSemantic proximity Read