Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Trans-interaction of risk loci 6p24.1 and 10q11.21 is associated with endothelial damage in coronary artery disease.

Atherosclerosis - 1 Dec 2022

Tay Kai Yi, Wu Kan Xing, Chioh Florence Wen Jing, Autio Matias Ilmari, Pek Nicole Min Qian, Narmada Balakrishnan Chakrapani, Tan Sock-Hwee, Low Adrian Fatt-Hoe, Lian Michelle Mulan, Chew Elaine Guo Yan, Lau Hwee Hui, Kao Shih Ling, Teo Adrian Kee Keong, Foo Jia Nee, Foo Roger Sik Yin, Heng Chew Kiat, Chan Mark Yan Yee, Cheung Christine

Abstract excerpt

BACKGROUND AND AIMS: Single nucleotide polymorphism rs6903956 has been identified as one of the genetic risk factors for coronary artery disease (CAD). However, rs6903956 lies in a non-coding locus on chromosome 6p24.1. We aim to interrogate the molecular basis of 6p24.1 containing rs6903956 risk alleles in endothelial disease biology. METHODS AND RESULTS: We generated induced pluripotent stem cells (iPSCs) from...

Read the complete abstract on PubMed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Coronary Artery Disease
Share to Endothelial Cells
Share to Genotype
Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 36435092
DOI: 10.1016/j.atherosclerosis.2022.10.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Trans-interaction of risk loci 6p24.1 and 10q11.21 is associated with endothelial damage in coronary artery disease.PMID 36435092Read ↗

<i>Trans</i> -interaction of risk loci 6p24.1 and 10q11.21 is associated with endothelial damage in coronary artery diseaseSemantic proximity Read ↗

Coronary Artery Disease Risk Variant rs6903956 Links to Endothelial Dysfunction via <i>PHACTR1</i> RegulationSemantic proximity Read ↗

A genetic variant at coronary artery disease and ischemic stroke locus 1p32.2 regulates endothelial responses to hemodynamicsSemantic proximity Read ↗

Multimodal CRISPR perturbations of GWAS loci associated with coronary artery disease in vascular endothelial cells.Semantic proximity Read ↗

The <i>9p21.3</i> Coronary Artery Disease Risk Locus Modulates Vascular Cell-State Transitions via Enhancer-Driven Regulation of <i>MTAP</i>Semantic proximity Read ↗

Genetic variant at coronary artery disease and ischemic stroke locus 1p32.2 regulates endothelial responses to hemodynamicsSemantic proximity Read ↗

9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response.Semantic proximity Read ↗

AP-1 signaling modulates cardiac fibroblast stress responsesSemantic proximity Read ↗

Myocardial Infarction-Associated SNP at 6p24 Interferes With MEF2 Binding and Associates With PHACTR1 Expression Levels in Human Coronary Arteries.Semantic proximity Read ↗

Allelic Variation at 9p21.3 Orchestrates Widespread RNA Splicing Shifts Governing Vascular Smooth Muscle Cell PlasticitySemantic proximity Read ↗

CRISPR perturbations at many coronary artery disease loci impair vascular endothelial cell functionsSemantic proximity Read ↗

The 9p21 locus does not affect risk of coronary artery disease through induction of type 1 interferons.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.