Article

CRISPR perturbations at many coronary artery disease loci impair vascular endothelial cell functions

2021-02-11

Abstract excerpt

<h4>ABSTRACT</h4> Genome-wide association studies have identified 161 genetic variants associated with coronary artery disease (CAD), but the causal genes and biological pathways remain unknown at most loci. Here, we used CRISPR knockout, inhibition and activation to target 1998 variants at 83 CAD loci to assess their effect on six vascular endothelial cell phenotypes (E-selectin, ICAM1, VCAM1, nitric oxide, reac...

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Literature Corpus work: 3996c114-8a3a-57b1-b1f0-7ad53c021ded
DOI: 10.1101/2021.02.10.430527

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