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Article

Multimodal CRISPR perturbations of GWAS loci associated with coronary artery disease in vascular endothelial cells.

PLoS genetics - 1 Mar 2023

Wünnemann Florian, Fotsing Tadjo Thierry, Beaudoin Mélissa, Lalonde Simon, Lo Ken Sin, Kleinstiver Benjamin P, Lettre Guillaume

Abstract excerpt

Genome-wide association studies have identified >250 genetic variants associated with coronary artery disease (CAD), but the causal variants, genes and molecular mechanisms remain unknown at most loci. We performed pooled CRISPR screens to test the impact of sequences at or near CAD-associated genetic variants on vascular endothelial cell functions. Using CRISPR knockout, inhibition and activation, we targeted...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36928188
DOI: 10.1371/journal.pgen.1010680
PMCID: PMC10047545

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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