Article
Epigenetic licensing of germline gene expression by maternal RNA in C. elegans.
Science (New York, N.Y.) - 2 Sept 2011
Johnson Cheryl L, Spence Andrew M
Abstract excerpt
RNA can act as a regulator of gene expression with roles in transposon silencing, antiviral defense, and cell fate determination. Here, we show that in Caenorhabditis elegans a maternal transcript of the sex-determining gene fem-1 is required to license expression of a wild-type fem-1 allele in the zygotic germ line. Females homozygous for fem-1 deletions produce heterozygous offspring exhibiting germline...
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