Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Knockout, Knockdown, and the Schrödinger Paradox: Genetic Immunity to Phenotypic Recapitulation in Zebrafish.

Genes - 3 Sept 2024

Arana Álvaro J, Sánchez Laura

Abstract excerpt

Previous research has highlighted significant phenotypic discrepancies between knockout and knockdown approaches in zebrafish, raising concerns about the reliability of these methods. However, our study suggests that these differences are not as pronounced as was once believed. By carefully examining the roles of maternal and zygotic gene contributions, we demonstrate that these factors significantly influence...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR-Cas Systems
Share to Gene Knockdown Techniques
Share to Gene Knockout Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Morpholinos

Share to Phenotype

Share to Zebrafish

Share to Zebrafish Proteins

Share to Zygote

Source

Open in PubMed Open full text

Identifiers

PMID: 39336755
DOI: 10.3390/genes15091164
PMCID: PMC11431394

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Knockout, Knockdown, and the Schrödinger Paradox: Genetic Immunity to Phenotypic Recapitulation in Zebrafish.PMID 39336755Read ↗

Reverse Genetics in Zebrafish: Mutants, Morphants, and Moving Forward.Semantic proximity Read ↗

Parental mutations influence wild-type offspring via transcriptional adaptation.Semantic proximity Read ↗

Zebrafish as a Model for the Study of Chaperonopathies.Semantic proximity Read ↗

Selective breeding modifies mef2ca mutant incomplete penetrance by tuning the opposing Notch pathway.Semantic proximity Read ↗

Genetic compensation is triggered by mutant mRNA degradationSemantic proximity Read ↗

Genotype-Phenotype Relationships in the Context of Transcriptional Adaptation and Genetic Robustness.Semantic proximity Read ↗

Characterization and Phenotypic Assessment of Zebrafish Disease Models for Splice Modulation Studies.Semantic proximity Read ↗

From Multi-Allele Fish to Non-Standard Environments, How ZFIN Assigns Phenotypes, Human Disease Models, and Gene Expression Annotations to GenesSemantic proximity Read ↗

Fishing forward and reverse: Advances in zebrafish phenomics.Semantic proximity Read ↗

Impact of maternal compensation on developmental phenotypes in a zebrafish model of severe congenital muscular dystrophy.Semantic proximity Read ↗

Evaluation of CRISPR gene-editing tools in zebrafishSemantic proximity Read ↗

The challenge of dissecting gene function in model organisms: Tools to characterize genetic mutants and assess transcriptional adaptation in zebrafish.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.