Article

Diversification of small RNA pathways underlies germline RNAi incompetence in wild <i>C. elegans</i> strains

2021-08-22

Abstract excerpt

<h4>ABSTRACT</h4> The discovery that experimental delivery of dsRNA can induce gene silencing at target genes revolutionized genetics research, by both uncovering essential biological processes and creating new tools for developmental geneticists. However, the efficacy of exogenous RNAi varies dramatically within the C. elegans population, raising questions about our understanding of RNAi in the lab relative to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 19578e65-474d-5db8-8aad-868abee18cb6
DOI: 10.1101/2021.08.21.457212

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Diversification of small RNA pathways underlies germline RNAi incompetence in wild <i>C. elegans</i> strainsDOI 10.1101/2021.08.21.457212Read

Resistance to germline RNA interference in a Caenorhabditis elegans wild isolate exhibits complexity and nonadditivity.Semantic proximity Read

Natural and unanticipated modifiers of RNAi activity in Caenorhabditis elegans.Semantic proximity Read

PPW-1, a PAZ/PIWI protein required for efficient germline RNAi, is defective in a natural isolate of C. elegans.Semantic proximity Read

Gene silencing by double-stranded RNA from <i>C. elegans</i> neurons reveals functional mosaicism of RNA interferenceSemantic proximity Read

Construction of a germline-specific RNAi tool in <i>C. elegans</i>Semantic proximity Read

Tissue- and sex-specific small RNAomes reveal sex differences in response to the environmentSemantic proximity Read

Beyond the reference: gene expression variation and transcriptional response to RNAi in <i>C. elegans</i>Semantic proximity Read

A cytoplasmic Argonaute protein promotes the inheritance of RNAiSemantic proximity Read

RNAi in C. elegans: soaking in the genome sequence.Semantic proximity Read

Natural Variation in Gene Expression Modulates the Severity of Mutant Phenotypes.Semantic proximity Read

Genome-wide association and environmental suppression of the mortal germline phenotype of wild <i>C. elegans</i>Semantic proximity Read

The rde-1 gene, RNA interference, and transposon silencing in C. elegans.Semantic proximity Read