Article
Genetically engineered multicistronic allele of Pmel yielding highly specific CreERT2-mediated recombination in the melanocyte lineage.
Pigment cell & melanoma research - 1 Jan 2023
Wilkinson Emma L, Brennan Louise C, Harrison Olivia J, Crane-Smith Zoe, Gautier Philippe, Keighren Margaret A, Budd Peter, Swaminathan Karthic, Machesky Laura M, Allinson Sarah L, Jackson Ian J, Mort Richard L
Abstract excerpt
Genetic approaches that allow lineage tracing are essential to our future understanding of melanocytes and melanoma. To date, the approaches used to label melanocytes in mice have relied on random integration of transgenes driven by the promoters of the Tyrosinase and Dopachrome tautomerase genes, knock-in to the Dopachrome tautomerase locus or knock-in to the Mlana locus in a bacterial artificial chromosome....
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