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Article

Generation of Pmel-dependent conditional and inducible Cre-driver mouse line for melanocytic-targeted gene manipulation.

Pigment cell & melanoma research - 1 Jan 2023

Nasrin Morsheda, Ahmed Osama, Han Xujun, Nojebuzzaman Md, Abo-Ahmed Ahmed I, Yazawa Shigenobu, Osawa Masatake

Abstract excerpt

Conditional and inducible gene targeting using Cre/loxP-mediated recombination is a powerful reverse genetics approach used to study spatiotemporal gene functions in specified cell types. To enable temporal gene manipulation in the melanocyte lineage, we established a novel inducible Cre-driver mouse line by targeting an all-in-one tetracycline/doxycycline (Dox)-inducible Cre expression cassette into the Pmel...

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PMID: 36318272
DOI: 10.1111/pcmr.13074

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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