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Article

The repeat domain of the melanosomal matrix protein PMEL17/GP100 is required for the formation of organellar fibers.

The Journal of biological chemistry - 28 Jul 2006

Hoashi Toshihiko, Muller Jacqueline, Vieira Wilfred D, Rouzaud Francois, Kikuchi Kanako, Tamaki Kunihiko, Hearing Vincent J

Abstract excerpt

Over 125 pigmentation-related genes have been identified to date. Of those, PMEL17/GP100 has been widely studied as a melanoma-specific antigen as well as a protein required for the formation of fibrils in melanosomes. PMEL17 is synthesized, glycosylated, processed, and delivered to melanosomes, allowing them to mature from amorphous round vesicles to elongated fibrillar structures. In contrast to other...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16682408
DOI: 10.1074/jbc.M601643200

Genes

TYR
TYRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The repeat domain of the melanosomal matrix protein PMEL17/GP100 is required for the formation of organellar fibers.PMID 16682408Read ↗

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