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Article

Deletion of macrophage Gpr101 disrupts their phenotype and function dysregulating host immune responses in sterile and infectious inflammation.

Biochemical pharmacology - 1 Jan 2023

Flak Magdalena B, Koenis Duco S, Gonzalez-Nunez Maria, Chopo-Pizarro Ana, Dalli Jesmond

Abstract excerpt

We recently found that the G protein coupled receptor GPR101 mediates the phagocyte-directed pro-resolving activities of RvD5n-3 DPA (n-3 docosapentaenoic acid-derived Resolvin D5). Herein, we investigated the endogenous role of this pro-resolving receptor in modulating macrophage biology using a novel mouse line where the expression of Gpr101 was conditionally deleted in macrophages (MacGpr101KO). Peritoneal...

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Identifiers

PMID: 36400250
DOI: 10.1016/j.bcp.2022.115348

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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