Article
G protein-coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice.
The Journal of clinical investigation - 1 Jul 2012
Osborn Olivia, Oh Da Young, McNelis Joanne, Sanchez-Alavez Manuel, Talukdar Saswata, Lu Min, Li Pingping, Thiede Lucinda, Morinaga Hidetaka, Kim Jane J, Heinrichsdorff Jan, Nalbandian Sarah, Ofrecio Jachelle M, Scadeng Miriam, Schenk Simon, Hadcock John, Bartfai Tamas, Olefsky Jerrold M
Abstract excerpt
Obesity-induced inflammation is a key component of systemic insulin resistance, which is a hallmark of type 2 diabetes. A major driver of this inflammation/insulin resistance syndrome is the accumulation of proinflammatory macrophages in adipose tissue and liver. We found that the orphan GPCR Gpr21 was highly expressed in the hypothalamus and macrophages of mice and that whole-body KO of this receptor led to a...
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