Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Resolvin D1 Polarizes Primary Human Macrophages toward a Proresolution Phenotype through GPR32.

Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2016

Schmid Mattia, Gemperle Claudio, Rimann Nicole, Hersberger Martin

Abstract excerpt

Resolvin D1 (RvD1) was shown to be a potent anti-inflammatory and proresolution lipid mediator in several animal models of inflammation, but its mechanism of action in humans is not clear. We show that the RvD1 receptor GPR32 is present on resting, proinflammatory M(LPS) and alternatively activated primary human M(IL-4) macrophages, whereas TGF-β and IL-6 reduce its membrane expression. Accordingly, stimulation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Inflammatory Agents
Share to Chemotaxis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Docosahexaenoic Acids

Share to Interleukin-1beta

Share to Interleukin-8

Share to Phagocytosis

Share to Receptors, G-Protein-Coupled

Share to Transforming Growth Factor beta

Source

Identifiers

PMID: 26969756
DOI: 10.4049/jimmunol.1501701

Genes

GPR32

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Resolvin D1 Polarizes Primary Human Macrophages toward a Proresolution Phenotype through GPR32.PMID 26969756Read ↗

17(R)-Resolvin D1 differentially regulates TLR4-mediated responses of primary human macrophages to purified LPS and live E. coli.Semantic proximity Read ↗

Resolvin D1 reduces inflammation in co-cultures of primary human macrophages and adipocytes by triggering macrophages.Semantic proximity Read ↗

Resolvin D1 Receptor Stereoselectivity and Regulation of Inflammation and Proresolving MicroRNAsSemantic proximity Read ↗

Frontline Science: Specialized proresolving lipid mediators inhibit the priming and activation of the macrophage NLRP3 inflammasome.Semantic proximity Read ↗

Resolvin D2-GPR18 Signaling on Myeloid Cells Limits Plaque NecrosisSemantic proximity Read ↗

Deletion of macrophage Gpr101 disrupts their phenotype and function dysregulating host immune responses in sterile and infectious inflammation.Semantic proximity Read ↗

Therapeutic Activity of Resolvin D1 (RvD1) in Murine MASHSemantic proximity Read ↗

IL-36γ signalling promotes a proinflammatory macrophage state that is associated with reduced lipid uptakeSemantic proximity Read ↗

The resolvin D and E biogenesis pathway regulates senescence and ageingSemantic proximity Read ↗

Immune responsive resolvin D1 programs peritoneal macrophages and cardiac fibroblast phenotypes in diversified metabolic microenvironment.Semantic proximity Read ↗

Resolvin D1 attenuates the inflammatory process in mouse model of LPS-induced keratitis.Semantic proximity Read ↗

Individual resolvin E family members work distinctly and in a coordinated manner in the resolution of inflammationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.