Article

Resolvin D2-GPR18 Signaling on Myeloid Cells Limits Plaque Necrosis

2023-04-05

Abstract excerpt

<h4>Introduction/Objective</h4> Dysregulated inflammation-resolution programs are associated with atherosclerosis progression. Inflammation-resolution is in part mediated by Resolvins, including Resolvin D2 (RvD2). RvD2, which activates a G-protein coupled receptor (GPCR) called GPR18, limits plaque progression. Cellular targets of RvD2 are not known. <h4>Approach and Results</h4> Here we developed humanized GPR...

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Literature Corpus work: 93bf09be-d649-5f8d-b283-7fd5c2707ff4
DOI: 10.1101/2023.04.03.535493

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