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Article

Neuropeptide S and G protein-coupled receptor 154 modulate macrophage immune responses

6 Apr 2006

Abstract excerpt

G protein-coupled receptor 154 (GPR154) is a recently discovered asthma susceptibility gene upregulated in the airways of asthma patients. We previously observed increased pulmonary mRNA expression of the murine ortholog Gpr154 in a mouse model of ovalbumin (OVA)-induced inflammation. However, the expression profile of GPR154 in leukocytes and the cellular functions of the receptor and its endogenous agonist...

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PMID: 16600990
DOI: 10.1093/hmg/ddl090

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