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Article

RASopathy mutations open new insights into the mechanism of BRAF activation.

Molecular cell - 17 Nov 2022

Dar Arvin C, Brady Donita C

Abstract excerpt

Spencer-Smith et al. (2022)1 investigate multiple functions of the BRAF cysteine-rich domain (CRD), finding distinct classes of RASopathy-associated BRAF mutations and unique features among RAF paralogs that may contribute to the spectrum of mutations observed in disease.

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Identifiers

PMID: 36400004
DOI: 10.1016/j.molcel.2022.10.034
PMCID: PMC9867872

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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