Article
RASopathy mutations provide functional insight into the BRAF cysteine-rich domain and reveal the importance of autoinhibition in BRAF regulation.
Molecular cell - 17 Nov 2022
Spencer-Smith Russell, Terrell Elizabeth M, Insinna Christine, Agamasu Constance, Wagner Morgan E, Ritt Daniel A, Stauffer Jim, Stephen Andrew G, Morrison Deborah K
Abstract excerpt
BRAF is frequently mutated in human cancer and the RASopathy syndromes, with RASopathy mutations often observed in the cysteine-rich domain (CRD). Although the CRD participates in phosphatidylserine (PS) binding, the RAS-RAF interaction, and RAF autoinhibition, the impact of these activities on RAF function in normal and disease states is not well characterized. Here, we analyze a panel of CRD mutations and show...
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