Article

Unveiling the Domain-Specific and RAS Isoform-Specific Details of BRAF Regulation

2023-04-24

Abstract excerpt

BRAF is a key member in the MAPK signaling pathway essential for cell growth, proliferation, and differentiation. Dysregulation or mutation of BRAF is often the underlying cause of various types of cancer. RAS, a small GTPase protein that acts upstream of BRAF, has been identified as a driver of up to one-third of all cancers. When BRAF interacts with RAS via the RAS binding domain (RBD) and membrane recruitment,...

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Literature Corpus work: cf37e483-555b-57de-b07f-b9d90965cdf6
DOI: 10.1101/2023.04.24.538112

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