Article
RAS internal tandem duplication disrupts GTPase-activating protein (GAP) binding to activate oncogenic signaling.
The Journal of biological chemistry - 10 Jul 2020
Nelson Andrew C, Turbyville Thomas J, Dharmaiah Srisathiyanarayanan, Rigby Megan, Yang Rendong, Wang Ting-You, Columbus John, Stephens Robert, Taylor Troy, Sciacca Drew, Onsongo Getiria, Sarver Anne, Subramanian Subbaya, Nissley Dwight V, Simanshu Dhirendra K, Lou Emil
Abstract excerpt
The oncogene RAS is one of the most widely studied proteins in cancer biology, and mutant active RAS is a driver in many types of solid tumors and hematological malignancies. Yet the biological effects of different RAS mutations and the tissue-specific clinical implications are complex and nuanced. Here, we identified an internal tandem duplication (ITD) in the switch II domain of NRAS from a patient with...
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