Back to search

Article

An In Vitro BRAF Activation Assay Elucidates Molecular Mechanisms Driving Disassembly of the Autoinhibited BRAF State

2025-08-19

Abstract excerpt

The RAF kinases (ARAF, BRAF and CRAF) are essential components of the RAS-ERK signaling pathway, which controls vital cellular processes and is frequently dysregulated in human disease. Notably, mutations that alter BRAF function are prominent drivers of human cancer and certain RASopathy disorders, making BRAF an important target for therapeutic intervention. Despite extensive research, several aspects of BRAF re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
4d64b1d6-6752-5f95-aefc-ab3a3fbf5631
DOI
10.1101/2025.08.19.671159
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
An In Vitro BRAF Activation Assay Elucidates Molecular Mechanisms Driving Disassembly of the Autoinhibited BRAF StateDOI 10.1101/2025.08.19.671159
Unveiling the Domain-Specific and RAS Isoform-Specific Details of BRAF RegulationSemantic proximity
Current Insights of BRAF Inhibitors in Cancer.Semantic proximity
Mechanism and inhibition of BRAF kinase.Semantic proximity
Mechanism and consequences of RAF kinase activation by small-molecule inhibitorsSemantic proximity
Autophosphorylation on S614 inhibits the activity and the transforming potential of BRAF.Semantic proximity
New insights into Raf regulation from structural analyses.Semantic proximity
Analyses of the oncogenic BRAFD594G variant reveal a kinase-independent function of BRAF in activating MAPK signaling.Semantic proximity
Functional characterization of a PROTAC directed against BRAF mutant V600E.Semantic proximity
Molecular Pathways and Mechanisms of BRAF in Cancer Therapy.Semantic proximity
MEK and RAF inhibitors for BRAF-mutated cancersSemantic proximity
Live-cell microscopy reveals small molecule inhibitor effects on MAPK pathway dynamics.Semantic proximity
Protomer Selectivity of RAF Inhibitors Within the RAS/RAF SignalosomeSemantic proximity
Select a neighboring publication to make it the new centre.