Article

<i>RAS</i> Internal Tandem Duplication Disrupts GAP-binding to Activate Oncogenic Signaling

2019-08-15

Abstract excerpt

Molecular testing of oncogenic RAS mutations in colorectal cancer (CRC) have led to increased identification of mutations in patients with CRC. NRAS -mutated CRC has not been well characterized because it is less common (<6%) than KRAS mutations. Here, we report a novel 10 amino acid internal tandem duplication (ITD) in NRAS , which disrupts the switch II domain, in a patient with widely disseminated CRC. Hots...

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Literature Corpus work: 7743b3ce-ed3a-5b11-b692-a1297a8ee731
DOI: 10.1101/737098

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