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Article

Analyses of the oncogenic BRAFD594G variant reveal a kinase-independent function of BRAF in activating MAPK signaling.

The Journal of biological chemistry - 21 Feb 2020

Cope Nicholas J, Novak Borna, Liu Zhiwei, Cavallo Maria, Gunderwala Amber Y, Connolly Matthew, Wang Zhihong

Abstract excerpt

Class 3 mutations in B-Raf proto-oncogene, Ser/Thr kinase (BRAF), that result in kinase-impaired or kinase-dead BRAF have the highest mutation frequency in BRAF gene in lung adenocarcinoma. Several studies have reported that kinase-dead BRAF variants amplify mitogen-activated protein kinase (MAPK) signaling by dimerizing with and activating WT C-Raf proto-oncogene, Ser/Thr kinase (CRAF). However, the structural...

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Identifiers

PMID: 31929109
DOI: 10.1074/jbc.RA119.011536
PMCID: PMC7039555

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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