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Article

Mechanism and inhibition of BRAF kinase.

Current opinion in chemical biology - 1 Dec 2022

Gunderwala Amber, Cope Nicholas, Wang Zhihong

Abstract excerpt

The role of BRAF in tumor initiation has been established, however, the precise mechanism of autoinhibition has only been illustrated recently by several structural studies. These structures uncovered the basis by which the regulatory domains engage in regulating the activity of BRAF kinase domain, which lead to a more complete picture of the regulation cycle of RAF kinases. Small molecule BRAF inhibitors...

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Identifiers

PMID: 36067564
DOI: 10.1016/j.cbpa.2022.102205
PMCID: PMC10396080

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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