Article

RASopathy Mutations Provide Functional Insight into the BRAF Cysteine-rich Domain and Demonstrate the Importance of Autoinhibition in BRAF Regulation

2021-10-02

Abstract excerpt

<h4>SUMMARY</h4> BRAF is frequently mutated in human cancer and the RASopathy syndromes, with RASopathy mutations often observed in the cysteine-rich domain (CRD). Although the CRD participates in phosphatidylserine (PS) binding, the RAS-RAF interaction, and RAF autoinhibition, the impact of these activities on RAF function in normal and disease states is not well-characterized. Here, we analyze a panel of CRD mu...

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Literature Corpus work: ba48e961-69b9-52e3-a3b1-1af4d79a928a
DOI: 10.1101/2021.10.01.462773

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