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Generation of cytochrome P450 enzyme-polymorphic human induced pluripotent stem cell lines with CYP2D610/CYP3A53C and CYP2D610/CYP2C192.

Stem cell research - 1 Dec 2022

Lee Jaehun, Kim Gyeongmin, Chi Kyun Yoo, Han Choongseong, Kim Jong-Hoon

Abstract excerpt

Cytochrome P450 (CYP) reaction phenotyping has become crucial for predicting drug reactions and side effects. Single nucleotide polymorphisms (SNPs) in CYP genes alter drug metabolism capacity and cause unexpected drug-related reactions. Here, we established two human induced pluripotent stem cell (hiPSC) lines with pharmacologically important SNPs in CYP2D6 in conjunction with CYP2C19 or CYP3A5 genes. These...

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Identifiers

PMID: 36399926
DOI: 10.1016/j.scr.2022.102970

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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