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Ethnically diverse pluripotent stem cells for drug development.

Trends in molecular medicine - 1 Dec 2012

Fakunle Eyitayo S, Loring Jeanne F

Abstract excerpt

Genetic variation is an identified factor underlying drug efficacy and toxicity, and adverse drug reactions, such as liver toxicity, are the primary reasons for post-marketing drug failure. Genetic predisposition to toxicity might be detected early in the drug development pipeline by introducing cell-based assays that reflect the genetic and ethnic variation of the expected treatment population. One challenge for...

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PMID: 23142148
DOI: 10.1016/j.molmed.2012.10.007

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