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Human induced pluripotent stem cell line with cytochrome P450 enzyme polymorphism (CYP2C192/CYP3A53C) generated from lymphoblastoid cells.

Stem cell research - 1 Mar 2018

Lee Jaehun, Woo Dong-Hun, Park Han-Jin, Park Kijung, Ko Duck Sung, Kim Jong-Hoon

Abstract excerpt

Cytochrome P450 (CYP) comprises a superfamily of monooxygenase responsible for the metabolism of xenobiotics and approximately 75% of drugs in use today. Thus, genetic polymorphisms in CYP genes contribute to interindividual differences in hepatic metabolism of drugs, affecting on individual drug efficacy and may cause adverse effects. Here, we generated a human induced pluripotent stem cell (hiPSC) line with...

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Identifiers

PMID: 29310059
DOI: 10.1016/j.scr.2017.12.014

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