Article
Increasing The Genetic Admixture of Available Lines of Human Pluripotent Stem Cells.
Scientific reports - 6 Oct 2016
Tofoli Fabiano A, Dasso Maximiliano, Morato-Marques Mariana, Nunes Kelly, Pereira Lucas Assis, da Silva Giselle Siqueira, Fonseca Simone A S, Costas Roberta Montero, Santos Hadassa Campos, da Costa Pereira Alexandre, Lotufo Paulo A, Bensenor Isabela M, Meyer Diogo, Pereira Lygia Veiga
Abstract excerpt
Human pluripotent stem cells (hPSCs) may significantly improve drug development pipeline, serving as an in vitro system for the identification of novel leads, and for testing drug toxicity. Furthermore, these cells may be used to address the issue of differential drug response, a phenomenon greatly influenced by genetic factors. This application depends on the availability of hPSC lines from populations with...
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