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Article

Estimation of drug-metabolizing capacity by cytochrome P450 genotyping and expression.

The Journal of pharmacology and experimental therapeutics - 1 Apr 2012

Temesvári Manna, Kóbori László, Paulik József, Sárváry Eniko, Belic Ales, Monostory Katalin

Abstract excerpt

Many undesired side effects or therapeutic failures of drugs are the result of differences or changes in drug metabolism, primarily depending on the levels and activities of cytochrome P450 (P450) enzymes. To assess whether P450 expression profiles can reflect hepatic drug metabolism, we compared P450 mRNA levels in the liver or peripheral leukocytes with the corresponding hepatic P450 activities. A preliminary...

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PMID: 22262920
DOI: 10.1124/jpet.111.189597

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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