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Article

How common are drug and gene interactions? Prevalence in a sample of 1143 patients with CYP2C9, CYP2C19 and CYP2D6 genotyping.

Pharmacogenomics - 1 Apr 2014

Verbeurgt Paul, Mamiya Tyler, Oesterheld Jessica

Abstract excerpt

AIM: Drug-drug interactions (DDIs) are a widely recognized major cause of adverse drug reactions, but two other newly described important types of interactions also exist: drug-gene interactions (DGIs) and drug-drug-gene interactions (DDGIs). A drug-gene interaction occurs when a patient's genetic CYP450 type (e.g., CYP2D6 poor metabolizer) affects that patient's ability to clear a drug. A drug-drug-gene...

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Identifiers

PMID: 24798722
DOI: 10.2217/pgs.14.6

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