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Article

Generation of cytochrome P450 polymorphic human induced pluripotent stem cell lines with defective CYP activities.

Stem cell research - 1 Aug 2018

Lee Jaehun, Woo Dong-Hun, Park Han-Jin, Ko Duck Sung, Kim Jong-Hoon

Abstract excerpt

Single nucleotide polymorphisms (SNPs) in cytochrome P450 (CYP) isoenzymes alter drug metabolism and pharmacodynamics. In particular, several SNPs within CYPs decrease CYP activities, resulting in a high plasma concentration of drugs and increasing adverse effect of commonly used drugs. Here, we generated two different human induced pluripotent stem cell (hiPSC) lines, which retain defective CYP2C19 or CYP3A5...

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Identifiers

PMID: 30071395
DOI: 10.1016/j.scr.2018.07.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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