Article
Stem cell‐derived hepatocytes as a predictive model for drug‐induced liver injury: are we there yet?
15 Jun 2012
Abstract excerpt
Amongst the different types of adverse drug reactions, drug-induced liver injury is the most prominent cause of patient morbidity and mortality. However, the current available hepatic model systems developed for evaluating safety have limited utility and relevance as they do not fully recapitulate a fully functional hepatocyte, and do not sufficiently represent the genetic polymorphisms present in the population....
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