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Article

Single-cell insights into maladaptive endothelial plasticity and therapeutic targets in diabetic vascular complications.

Cardiovascular diabetology - 6 May 2026

Alnuaimi Noura S, Lößlein Lena, Mousa Mira, Khader Thanumol Abdul, Alkhaaldi Ayesha, Azzam Sarah K, Van Craenenbroeck Amaryllis H, Ashraf Syed Salman, Carmeliet Peter, Alsafar Habiba

Abstract excerpt

Endothelial plasticity, the capacity of endothelial cells (ECs) to reversibly alter their phenotype in response to environmental cues, typically enables adaptive vascular remodeling and tissue homeostasis. In diabetes, this plasticity becomes maladaptive, driving pathological transitions across interconnected axes: dysregulated angiogenesis with barrier destabilization, inflammatory reprogramming through...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42092877
DOI: 10.1186/s12933-026-03187-z
PMCID: PMC13317339

Genes

ANGPTL4
MFAP4
SETD7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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