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Article

Apelin directs endothelial cell differentiation and vascular repair following immune-mediated injury

17 Nov 2019

Abstract excerpt

Sustained, indolent immune injury of the vasculature of a heart transplant limits long-term graft and recipient survival. This injury is mitigated by a poorly characterized, maladaptive repair response. Vascular endothelial cells respond to proangiogenic cues in the embryo by differentiation to specialized phenotypes, associated with expression of apelin. In the adult, the role of developmental proangiogenic cues...

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PMID: 31738185
DOI: 10.1172/jci128469

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