Article

Single cell compendium of muscle microenvironment in peripheral artery disease reveals altered endothelial diversity and LYVE1 <sup>+</sup> Macrophage Activation

2023-06-22

Abstract excerpt

<h4> A bstract </h4> Peripheral artery disease (PAD) results from atherosclerosis and chronic narrowing of lower limb arteries leading to decreased muscle perfusion. Current treatments are suboptimal, partly due to limited understanding of PAD muscle pathology. Here we use scRNAseq and spatial transcriptomics to analyze the composition of the muscle microenvironment in non-ischemic and PAD patients. We identifi...

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Literature Corpus work: 16fb506f-a3b5-5a2c-8a1d-5f2cbfd05401
DOI: 10.1101/2023.06.21.545899

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