Article
Interferon-beta signaling is enhanced in patients with insufficient coronary collateral artery development and inhibits arteriogenesis in mice.
Circulation research - 23 May 2008
Schirmer Stephan H, Fledderus Joost O, Bot Pieter T G, Moerland Perry D, Hoefer Imo E, Baan Jan, Henriques José P S, van der Schaaf René J, Vis Marije M, Horrevoets Anton J G, Piek Jan J, van Royen Niels
Abstract excerpt
Stimulation of collateral artery growth in patients has been hitherto unsuccessful, despite promising experimental approaches. Circulating monocytes are involved in the growth of collateral arteries, a process also referred to as arteriogenesis. Patients show a large heterogeneity in their natural arteriogenic response on arterial obstruction. We hypothesized that circulating cell transcriptomes would provide...
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