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Article

Estimating the In Vivo Function of CYP2D6 Alleles through Population Pharmacokinetic Modeling of Brexpiprazole.

Clinical pharmacology and therapeutics - 1 Feb 2023

Frederiksen Trine, Areberg Johan, Raoufinia Arash, Schmidt Ellen, Stage Tore Bjerregaard, Brøsen Kim

Abstract excerpt

Accurate prediction of CYP2D6 phenotype from genotype information is important to support safe and efficacious pharmacotherapy with CYP2D6 substrates. To facilitate accurate CYP2D6 genotype-phenotype translation, there remains a need to investigate the enzyme activity associated with individual CYP2D6 alleles using large clinical data sets. This study aimed to quantify and compare the in vivo function of...

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PMID: 36350097
DOI: 10.1002/cpt.2791
PMCID: PMC10099095

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