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Article

Role of P34S, G169R, R296C, and S486T Substitutions in Ligand Access and Catalysis for Cytochrome P450 2D6 Allelic Variants CYP2D614A and CYP2D614B.

Drug metabolism and bioanalysis letters - 1 Jan 2022

Dong Amelia Nathania, Ahemad Nafees, Pan Yan, Palanisamy Uma Devi, Yiap Beow Chin, Ong Chin Eng

Abstract excerpt

BACKGROUND: Genetic polymorphism of cytochrome P450 (CYP) contributes to variability in drug metabolism, clearance, and response. This study aimed to investigate the functional and molecular basis for altered ligand binding and catalysis in CYP2D6*14A and CYP2D6*14B, two unique alleles common in the Asian population. METHODS: CYP proteins expressed in Escherichia coli were studied using the substrate 3-cyano-7-...

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PMID: 35049443
DOI: 10.2174/1872312815666220113125232

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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