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Article

Improved Prediction of CYP2D6 Catalyzed Drug Metabolism by Taking Variant Substrate Specificities and Novel Polymorphic Haplotypes into Account.

Clinical pharmacology and therapeutics - 1 Jul 2025

Johansson Inger, Xanthopoulou Emmanouella M, Zhou Yitian, Sanchez-Spitman Anabel, van der Lee Maaike, Wollmann Birgit M, Størset Elisabet, Swen Jesse J, Guchelaar Henk-Jan, Molden Espen, Jukic Marin M, Ingelman-Sundberg Magnus

Abstract excerpt

The polymorphic CYP2D6 enzyme plays a pivotal role in the metabolism of approximately 25% of clinically prescribed drugs. However, the impact of specific genetic variants on the interindividual variability in CYP2D6-mediated drug metabolism remains insufficiently quantified. This translational study sought to address this gap by analyzing the genotypes and phenotypes of patients in two large clinical cohorts,...

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Share to Cytochrome P-450 CYP2D6
Share to Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Haplotypes

Share to Phenotype

Share to Polymorphism, Genetic

Share to Risperidone

Share to Substrate Specificity

Share to Tamoxifen

Source

Open in PubMed Open full text

Identifiers

PMID: 40261922
DOI: 10.1002/cpt.3680
PMCID: PMC12166262

Genes

CYP3A4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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