Article
Population genomic analysis of 962 whole genome sequences of humans reveals natural selection in non-coding regions.
PloS one - 1 Jan 2015
Yu Fuli, Lu Jian, Liu Xiaoming, Gazave Elodie, Chang Diana, Raj Srilakshmi, Hunter-Zinck Haley, Blekhman Ran, Arbiza Leonardo, Van Hout Cris, Morrison Alanna, Johnson Andrew D, Bis Joshua, Cupples L Adrienne, Psaty Bruce M, Muzny Donna, Yu Jin, Gibbs Richard A, Keinan Alon, Clark Andrew G, Boerwinkle Eric
Abstract excerpt
Whole genome analysis in large samples from a single population is needed to provide adequate power to assess relative strengths of natural selection across different functional components of the genome. In this study, we analyzed next-generation sequencing data from 962 European Americans, and found that as expected approximately 60% of the top 1% of positive selection signals lie in intergenic regions, 33% in...
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