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PRIMAL: Fast and accurate pedigree-based imputation from sequence data in a founder population.

PLoS computational biology - 1 Mar 2015

Livne Oren E, Han Lide, Alkorta-Aranburu Gorka, Wentworth-Sheilds William, Abney Mark, Ober Carole, Nicolae Dan L

Abstract excerpt

Founder populations and large pedigrees offer many well-known advantages for genetic mapping studies, including cost-efficient study designs. Here, we describe PRIMAL (PedigRee IMputation ALgorithm), a fast and accurate pedigree-based phasing and imputation algorithm for founder populations. PRIMAL incorporates both existing and original ideas, such as a novel indexing strategy of Identity-By-Descent (IBD)...

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Identifiers

PMID: 25735005
DOI: 10.1371/journal.pcbi.1004139
PMCID: PMC4348507

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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