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Article

MR-DoC2: Bidirectional Causal Modeling with Instrumental Variables and Data from Relatives.

Behavior genetics - 1 Feb 2023

Castro-de-Araujo Luis F S, Singh Madhurbain, Zhou Yi, Vinh Philip, Verhulst Brad, Dolan Conor V, Neale Michael C

Abstract excerpt

Establishing causality is an essential step towards developing interventions for psychiatric disorders, substance use and many other conditions. While randomized controlled trials (RCTs) are considered the gold standard for causal inference, they are unethical in many scenarios. Mendelian randomization (MR) can be used in such cases, but importantly both RCTs and MR assume unidirectional causality. In this paper,...

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Identifiers

PMID: 36322200
DOI: 10.1007/s10519-022-10122-x
PMCID: PMC9823046

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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