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Article

Network Mendelian randomization: using genetic variants as instrumental variables to investigate mediation in causal pathways.

International journal of epidemiology - 1 Apr 2015

Burgess Stephen, Daniel Rhian M, Butterworth Adam S, Thompson Simon G

Abstract excerpt

BACKGROUND: Mendelian randomization uses genetic variants, assumed to be instrumental variables for a particular exposure, to estimate the causal effect of that exposure on an outcome. If the instrumental variable criteria are satisfied, the resulting estimator is consistent even in the presence of unmeasured confounding and reverse causation. METHODS: We extend the Mendelian randomization paradigm to investigate...

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Identifiers

PMID: 25150977
DOI: 10.1093/ije/dyu176
PMCID: PMC4469795

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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