Article
Prevalence of arps10, fd, pfmdr-2, pfcrt and pfkelch13 gene mutations in Plasmodium falciparum parasite population in Uganda.
PloS one - 1 Jan 2022
Ocan Moses, Ashaba Fred Katabazi, Mwesigwa Savannah, Edgar Kigozi, Kamya Moses R, Nsobya Sam L
Abstract excerpt
In Uganda, Artemether-Lumefantrine and Artesunate are recommended for uncomplicated and severe malaria respectively, but are currently threatened by parasite resistance. Genetic and epigenetic factors play a role in predisposing Plasmodium falciparum parasites to acquiring Pfkelch13 (K13) mutations associated with delayed artemisinin parasite clearance as reported in Southeast Asia. In this study, we report on...
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