Article
Artemisinin resistance phenotypes and K13 inheritance in a Plasmodium falciparum cross and Aotus model.
Proceedings of the National Academy of Sciences of the United States of America - 4 Dec 2018
Sá Juliana M, Kaslow Sarah R, Krause Michael A, Melendez-Muniz Viviana A, Salzman Rebecca E, Kite Whitney A, Zhang Min, Moraes Barros Roberto R, Mu Jianbing, Han Paul K, Mershon J Patrick, Figan Christine E, Caleon Ramoncito L, Rahman Rifat S, Gibson Tyler J, Amaratunga Chanaki, Nishiguchi Erika P, Breglio Kimberly F, Engels Theresa M, Velmurugan Soundarapandian, Ricklefs Stacy, Straimer Judith, Gnädig Nina F, Deng Bingbing, Liu Anna, Diouf Ababacar, Miura Kazutoyo, Tullo Gregory S, Eastman Richard T, Chakravarty Sumana, James Eric R, Udenze Kenneth, Li Suzanne, Sturdevant Daniel E, Gwadz Robert W, Porcella Stephen F, Long Carole A, Fidock David A, Thomas Marvin L, Fay Michael P, Sim B Kim Lee, Hoffman Stephen L, Adams John H, Fairhurst Rick M, Su Xin-Zhuan, Wellems Thomas E
Abstract excerpt
Concerns about malaria parasite resistance to treatment with artemisinin drugs (ARTs) have grown with findings of prolonged parasite clearance t1/2s (>5 h) and their association with mutations in Plasmodium falciparum Kelch-propeller protein K13. Here, we describe a P. falciparum laboratory cross of K13 C580Y mutant with C580 wild-type parasites to investigate ART response phenotypes in vitro and in vivo. After...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.