Article
Introduction of F446I mutation in the K13 propeller gene leads to increased ring survival rates in Plasmodium falciparum isolates.
Malaria journal - 5 Jul 2018
Wang Jing, Huang Yufu, Zhao Yuemeng, Ye Run, Zhang Dongmei, Pan Weiqing
Abstract excerpt
BACKGROUND: Mutations in the Plasmodium falciparum k13 gene are associated with artemisinin (ART) resistance. However, it is unclear whether the F446I mutation, the most prevalent allele at the China-Myanmar border and north of Myanmar, is associated with ART resistance. Therefore, the aim of this study was to investigate the role of this mutation in ART resistance by generating transgenic parasites expressing...
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