Article
Genetic background and PfKelch13 affect artemisinin susceptibility of PfCoronin mutants in Plasmodium falciparum.
PLoS genetics - 1 Dec 2020
Sharma Aabha I, Shin Sara H, Bopp Selina, Volkman Sarah K, Hartl Daniel L, Wirth Dyann F
Abstract excerpt
Malaria continues to impose a significant health burden in the continent of Africa with 213 million cases in 2018 alone, representing 93% of cases worldwide. Because of high transmission of malaria within the continent, the selection pressures to develop drug resistance in African parasites are distinct compared to the rest of the world. In light of the spread of resistance to artemisinin conferred by the C580Y...
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