Role of novel mutations in food vacuole transporters beyond K13-mediated artemisinin resistance in Plasmodium falciparum.

doi:10.1128/aac.00293-25

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Article

Role of novel mutations in food vacuole transporters beyond K13-mediated artemisinin resistance in Plasmodium falciparum.

Antimicrobial agents and chemotherapy - 5 Nov 2025

Junaid Iqbal Taliy, Panda Ashutosh, Deshmukh Arunaditya, Sardar Rahila, Narwal Monika, Agrawal Prakhar, Prakash Neha, Akhtar Asif, Dey Amit Kumar, Singh Suneet Shekhar, Mridha Saptarshi, Mochi Jigneshkumar, Parveen Sadaf, Kumar Mohit, Nagar Rashi, Gaur Naseem, Gupta Dinesh, Mohmmed Asif, Kaur Inderjeet, Karmodiya Krishanpal, Malhotra Pawan

Abstract excerpt

Malaria remains one of the leading causes of morbidity and mortality worldwide, mainly because of the emergence of drug resistance against current antimalarials. The Plasmodium falciparum food vacuole (FV) proteins, P. falciparum chloroquine (CQ) resistance transporter (PfCRT), PfMDR1 and the cytosolic protein PfKelch13 have been linked to CQ and artemisinin resistance, respectively. Here, we aimed to identify...

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PMID: 41025646
DOI: 10.1128/aac.00293-25
PMCID: PMC12587573

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