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Plasmodium falciparum resistance to ACTs: Emergence, mechanisms, and outlook

26 May 2021

Abstract excerpt

Emergence and spread of resistance in Plasmodium falciparum to the frontline treatment artemisinin-based combination therapies (ACTs) in the epicenter of multidrug resistance of Southeast Asia threaten global malaria control and elimination. Artemisinin (ART) resistance (or tolerance) is defined clinically as delayed parasite clearance after treatment with an ART drug. The resistance phenotype is restricted to...

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PMID: 34090067
DOI: 10.1016/j.ijpddr.2021.05.007

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