Article

Single cell multi-omic whole genome sequencing and chromatin accessibility profiling reveals genome-epigenome coevolution in colorectal cancer

2025-04-18

Abstract excerpt

Epigenetic alterations co-evolve with genetic mutations to drive carcinogenesis and treatment response. Resolving genome-epigenome coevolution requires accurate multi-omic single cell measurement. Here we develop a new technology called “double ATAC” (dATAC) for high-throughput, high-quality, concurrent whole genome sequencing and chromatin accessibility profiling of individual somatic cells. dATAC is a “one pot”...

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Literature Corpus work: 707f0f58-ea26-5f01-aed5-ec2edba5ae63
DOI: 10.1101/2025.04.15.648959

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